The NextSeq 550AR Sequencer employs reversible terminator-based sequencing technology and is clinically used for sequencing deoxyribonucleic acid (DNA) derived from human samples to detect genetic sequence variations that may be associated with diseases or predispositions. In clinical settings, the instrument can be used in conjunction with in vitro diagnostic reagents approved by the National Medical Products Administration and its accompanying software for targeted analysis. It is not intended for whole human genome sequencing or de novo sequencing.